Hereditary Angioedema (HAE), first described in the late 19th century, is a rare genetic disease due to C1 inhibitor (C1-INH) deficiency [1,2], clinically characterized by recurring episodes of skin swelling, abdominal pain, and life-threatening upper airway obstruction due to the involvement of subcutaneous and submucosal areas [3,4]. The gene discussed is SERPING1; the disease is hyperinsulinemic hypoglycemia, familial, 4.