POMC and congenital adrenal hyperplasia: Another hypothesis is consistent with the possibility that the tumors originate from the proliferation of pluripotent fetal Leydig cells (FLCs) that contain ACTH, AII, and Luteinizin hormone (LH)/human Corionic Gonadotrophin (hCG) receptors: the presence of ACTH receptors on FLCs could explain the cell proliferation in males with CAH during fetal life due to chronic exposure to elevated ACTH levels.