Before genetic diagnosis for IQSEC2, descriptive diagnosis before the genetic diagnosis of IQSEC2-related encephalopathy was reported for n = 7 patients (#2, #5, #6, #10, #12, #13, #17), whereas a psychiatric disorder of unlikely genetic origin was suspected for n = 3 patients (#3, #9, #19). This evidence concerns the gene IQSEC2 and psychiatric disorder.