Niemann–Pick disease type C (NP–C) is a rare (<1/100,000 births) [51], autosomal recessive neurodegenerative disease caused by mutations in the NPC1 or NPC2 gene that lead to impaired intracellular lipid trafficking and excess storage of cholesterol and glycophospholids in the brain, liver, and other tissues [52]. The gene discussed is NPC1; the disease is Niemann-Pick disease type C.