ABCB11 and Cholestatic liver disease: In some patients, benign variants (single nucleotide polymorphisms (SNP)) described to predispose to cholestatic liver disease could be detected in heterozygous status [16,17], e.g., ABCB11 variant c.1772A>G, p.(Asn591Ser) or ABCB11 variant c.1331T>C, p.(Val444Ala).