Specifically, the roles played by two angiogenic factors—soluble fms-like tyrosine kinase 1 (sFlt-1), which is an antiangiogenic protein, and placental growth factor (PlGF), which is a pro-angiogenic protein—has been extensively researched in the recent literature, with relevant data generated regarding their ability to predict pre-eclampsia, as well as intrauterine growth restriction, pre-term delivery, and stillbirth [13]. This evidence concerns the gene PGF and fetal growth restriction.