This is the first preliminary report that describes how the testicular tissues from two CO patients with cells immune-positive to POU5F1, PLAP, and KIT overexpressed the hsa-miR-371-373 cluster and hsa-miR-367 and under-expressed the LATS2 and IGF1R genes, similar to what was observed in TGCT tissues. The gene discussed is POU5F1; the disease is testicular germ cell tumor.