In the TCGA data, the most common variants in TP53 were p.Arg175His (n = 17) and p.Arg213Ter (n = 13), both associated with Li-Fraumeni syndrome [37], p.Arg248Trp (n = 13), which falls within the same hotspot as p.Arg273His and p.Arg282Trp, and p.Arg273His (n = 12), as in our own cohort (supplementary). Here, TP53 is linked to Li-Fraumeni syndrome.