Survival curves were plotted and stratified by categorical variables (AJCC stage, AJCC grade, presence or absence of pathogenic variant (PV) in each gene of interest (BRCA2, TP53 or KRAS), presence of frequent specific KRAS mutations (KRAS-12D, KRAS-G12S, KRAS-G13D), tumor location, tumor grade, and TMB category) (Figure 6). This evidence concerns the gene TP53 and neoplasm.