In several tumor types, particularly breast, ovarian, pancreatic, and prostate cancers, a strong correlation was observed between increased gLOH and biallelic alterations in other HR genes beyond BRCA1 and BRCA2, including BARD1, PALB2, FANCC, RAD51C, and RAD51D. The gene discussed is BARD1; the disease is Familial prostate cancer.