We found CRP levels to be elevated in more severe disease groups of noninfective patients compared to the least severe disease group defined by both the CTP stage (A: 3.81 [1.10–12.74]; B: 10.05 [4.83–32.56]; C: 13.73 [6.24–31.53]) and AD score/ACLF (<50: 6.385 [3.29–26.43]; ≥50: 16.31 [6.95–36.01]; ACLF 12.59 [6.98–28.48]. The gene discussed is CRP; the disease is Alzheimer disease.