In the report, TCONS_00016233 overexpression worsened sepsis-induced mouse AKI by down-regulating miR-22-3p, thus increasing the miR-22-3p target, apoptosis-inducing factor mitochondrion-associated 1 (AIFM1), leading to apoptosis [81]. The gene discussed is AIFM1; the disease is acute kidney injury.