Autoimmune hemolytic anemia (AIHA) is an acquired autoimmune disease characterized by the increased destruction of autologous red blood cells (RBCs) due to the presence of immunoglobulin (Ig)G, IgM, IgA, or complements (usually C3d) bound to RBC membrane antigens [1,2,3]. The gene discussed is CD40LG; the disease is autoimmune hemolytic anemia.