Glioblastoma multiforme, the most aggressive adult brain tumor, has been the target of other studies involving protein citrullination in an attempt to elucidate the molecular mechanisms underlying its high recurrence rate and ability to infiltrate distal brain sites, aimed at investigating the role of PAD-mediated pathways in the release of extracellular vesicles (EVs) by cancer cells. This evidence concerns the gene PADI4 and cancer.