HSPD1 and periodontal disorder: To date, the toxicity of GroEL in prokaryotic organisms has been studied preliminarily only in several bacteria that cause specific tissue diseases, such as Porphyromonas gingivalis, in which GroEL could aggravate the alveolar inflammation and bone loss of rats, leading to the occurrence of periodontal disease [34], and Mycobacterium tuberculosis, in which the grol gene mutant could not produce granulomatous inflammation in animal experiments [35].