Indeed, only one study analyzed the in vitro effects of adiponectin on lymphoblastic cells, reporting that adiponectin did not produce any inhibition of cell cycle progression, as well as an increase in cell death while regulating different genes, such as CD22, CDH1, IFNG, LCK, MSH2, SPINT2, implicated in the progression of leukemia [21]. The gene discussed is SPINT2; the disease is leukemia.