The most common mutations found in HCC are found in the TERT promoter (60% of tumors), TP53 (50%), catenin beta 1 (CTNNB1) (40%), AT-rich interaction domain 1A (ARID1A) (10–20%), and axis inhibition protein 1 (AXIN1) (10–15%). The gene discussed is TP53; the disease is hepatocellular carcinoma.