JADE2 and non-small cell lung carcinoma: However, we then assessed JADE2 mRNA levels with actual TMB in NSCLC, there was an actual negative correlation between JADE2 mRNA and TMB in LUAD (Figure 6C; Spearman’s correlation −0.34; p = 1.9 × 10−7), and no correlation between TMB and JADE2 mRNA in LUSC (Figure 6D).