Whether or not mutated forms of these genes play functional roles in NSCLC tumorigenesis has yet to be elucidated, but preliminary analysis by us suggests that high expression of HECW2 and ZNF800 mRNA is associated with a better OS, whilst high expression of HECW1 and KRT34 is associated with poor OS, and an assessment of these markers for prognostic value linked to mutational status may be warranted. The gene discussed is HECW1; the disease is non-small cell lung carcinoma.