NTRK2 and depressive symptom measurement: To discover the participation of receptor TrkB.T1 in depressive-like behavior, here we chose the Antidepressant-Sensitive Catalepsy (ASC) mouse strain: a genetic model of depression that has been developed by backcrossing predisposed-to-catalepsy CBA/Lac mice and catalepsy-prone AKR/J mice [18,19].