IL18 and Cowden syndrome 1: All of them presented a hyperinflammatory cytokine pattern and they exhibited high levels of interleukin (IL)-6 (mean value: 416.1 pg/mL), antagonist interleukin 1 receptor (IL-1RA) (mean value: 261.7 pg/mL), and IL-18 (mean value: 77.4 pg/mL), which are particularly higher in CS.