In loci related to diseases of predisposition to viral infection and diseases of immune dysregulation, we identified two monoallelic SNPs, the p.Phe8Ser variant (rs2229207) in the IFNAR2 gene with 8.2% European MAF (eMAF), which was previously related to COVID-19 severity, and the p.Val181Met (rs117556162) (eMAF: 5%) variant in the CARMIL2 gene. This evidence concerns the gene IFNAR2 and viral infectious disease.