For example, miR-105 carried within EVs derived from the metastatic MDA-MB-231 breast cancer cell line increases metastasis by facilitating endothelial cell barrier destruction via the downregulation of the tight junction zonula occludens 1 (ZO-1) protein [177] and Golgi integral membrane protein 4 (GOLIM4) [178]. The gene discussed is GOLIM4; the disease is breast cancer.