The treatment of metastatic cancer remains challenging, and in fact the study by Haj-Shomaly et al., 2022, suggests that paclitaxel chemotherapy, while effective in some cancer instances, may also promote tumor metastasis in the lung through its ability to rapidly induce ECM remodeling mediated by CD8+ T cells expressing lysyl oxidase (LOX), a potent ECM remodeling enzyme [144]. Here, LOX is linked to cancer.