Biagoni et al. showed that urokinase plasminogen activator surface receptor (uPAR) containing exosome-like vesicles released from melanoma cells led to an increase in pro-angiogenesis of both human microvascular endothelial cells (HMVECs) and endothelial colony-forming cells (ECFCs), which they demonstrated was as a result of tumor exosome-like vesicle-mediated induction of vascular endothelial cadherin (VE-Cadherin), uPAR, and EGFR protein expression in endothelial cells [132]. Here, CDH5 is linked to melanoma.