It is noticed that DHME reduced p-STAT3 (Y705) levels in HCT-15 and LoVo cells in a dose- and time-dependent manner, illustrating that DHME suppressed the constitutive STAT3 activation inherently present in CRC cells (Figure 2A,B and Supplementary Figure S1A,B). This evidence concerns the gene STAT3 and colorectal carcinoma.