Immunoblotting revealed that DHME evidently increased the levels of cleaved PARP (c-PARP) in vector control clones while failing to promote PARP cleavage when BCL-2 was not downregulated (Figure 4C and Supplementary Figure S3C), proving that DHME lowers BCL-2 levels to induce CRC cell apoptosis. Here, BCL2 is linked to colorectal carcinoma.