MT-ND6 and Bloom syndrome: Upon comparing the level of short cf-mtDNA in plasma from HC and Obese BS patients, we found that the level of plasma cf-mtDNA ND6 fragments was five times greater in Obese BS (0.05 ± 0.03) compared to HC (0.01 ± 0.01, p = 0.0026, Figure 1A).