NFE2L2 and myeloid sarcoma: Since TrxR1/Nrf2 signaling plays a prominent role in fine tuning the overall antioxidant and anti-inflammatory balance through the control of systemic and neuronal inflammation, which are crucial players in the development of RRMS, the effects of a well-known gold compound, AFN, on the oxidant–antioxidant equilibrium, inflammatory cytokines, and clinical features were tested in an RR-EAE SJL/J mouse model of MS.