COL11A1 and neoplasm: And lastly, as COL11A1 is a stromal marker (directly related to infiltration), its use represents a breakthrough, especially in small samples (e.g., CNB) since, unlike markers of myoepithelial cell loss that require infiltration area to be present [38,39], COL11A1 is able to detect stromal changes regardless of whether there is an infiltrative tumor component or not.