POMC and Chagas disease: Corticotropin-releasing factor (CRH), adrenocorticotropin (ACTH), and glucocorticoids play an integral part in stress response mechanisms, modulation of proinflammatory cytokines production, regulation of peripheral immune response regulation and neuroimmunoendocrine interactions regulating peripheral immunity response regulation; targeting this system could provide therapeutic approaches both human and experimental forms of Chagas disease [101].