Decreased levels of peroxisome proliferator-activated receptor coactivator 1 (PGC1 α), nuclear factor erythroid 2-related factor 2 (Nrf2), and mitochondrial transcription factor A (TFAM) have been seen in cellular and murine models of AD and in postmortem brain tissue of AD patients [65,66]. This evidence concerns the gene NFE2L2 and Alzheimer disease.