LRP1 and early-onset autosomal dominant Alzheimer disease: Moreover, when LRP1 is affected by oxidative stress and its function is impaired, it could disrupt the normal clearance mechanism of amyloid-beta peptide from the brain, potentially contributing to its accumulation having detrimental effects in Alzheimer’s disease, as several studies pointed out, where it was suggested that LRP1 activity is diminished in AD [239].