PIK3CA and nonpapillary renal cell carcinoma: Genetic mutations in ccRCC are described in the following genes: the von Hippel–Lindau tumor suppressor gene (VHL, most frequent, up to 50%), PBMR1 (up to 40%), BAP1 (up to 15%), and other genes recounted as SET Domain Containing 2 (SET D2), Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA), and also TSC Complex Subunit 1 and 2 (TSC1/2) [23,24,25,26].