Considering that in animal models of anti-NMDAR encephalitis, behavioral impairments can recover without treatment after a 14-day cessation of antibody injection [28,29], whereas, in the animal model of anti-IgLON5 disease, motor impairment persists even after a 3-month cessation of antibody injection, we believe this indicates a long-term chronic effect of the antibodies. This evidence concerns the gene IGLON5 and viral encephalitis.