In a large cohort of COVID-19 patients, 48.5% had NT-proBNP levels above the recommended cut-off values for the identification of acute HF as recommended by the Heart Failure Association of the European Society of Cardiology, and NT-proBNP was independently associated with all-cause mortality at a median follow-up of 53 days after adjusting for all potentially relevant confounders [HR 1.28 (1.13–1.44) per logarithmic unit] [24]. This evidence concerns the gene NPPB and COVID-19.