CXCL8 and Increased total leukocyte count: In MPNs, as described above (see also Table 2), data from Ayalew Tefferi’s laboratory demonstrated that higher levels of circulating CXCL8 in (P)MF were an independent predictive factor of reduced survival on multivariate analysis, which included risk stratification according to the DIPSS plus as a covariate; moreover, they were correlated with leukocytosis, anemia, constitutional symptoms, increased circulating blasts, and a higher risk of leukemic transformation [16,17].