NLRP3 and Splenomegaly: The authors analyzed expression levels and genetic polymorphisms of inflammasome genes NLRP3, NF-KB, CARD8, IL1B, and IL18 on BM cells of MPN patients, demonstrating that an increased expression of NLRP3 inflammasome-related genes was associated with JAK2V617F mutation, WBC counts, and splenomegaly [32].