The Romanian standard–of-care treatment regarding the maximum tolerated dose for T2DM for the metformin group is represented by metformin, or metformin plus insulin; in the SGLT-2i group by metformin plus SGLT-2i or metformin plus SGLT-2i plus insulin; in the GLP-1 RA group by metformin plus GLP-1 RAs plus insulin, as shown in Table 2; and, alongside with CV treatment of interest, respectively, beta-blockers (BB), calcium-channel blockers (CCB), angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB) or statins and, when needed, diuretics. The gene discussed is INS; the disease is type 2 diabetes mellitus.