A systematic review and meta-analysis by Patoulias et al. [48] reported that GLP-1 RAs offered better HbA1c reduction with −0.38% (95% CI −0.55, −0.22) as compared to SGLT-2i, but with similar improvements in body weight −0.29 kg (95% CI −1.24, 0.66) and fasting plasma glycaemia in T2DM. The gene discussed is GCG; the disease is type 2 diabetes mellitus.