SCN5A and Brugada syndrome: Initially, patch clamp experiments were performed manually, but in recent years, the pathogenicity of SCN5A, KCNQ1, and KCNH2 variants involved in the inherited cardiac channelopathies Brugada syndrome and long QT syndrome types 1 and 2, respectively, have also been determined using high-throughput reclassification assays based on automated patch clamp devices [25,39,40,41,42,43,44].