The concentration of leptin in the serum was significantly higher in both of the groups that received nifedipine i.a., including the healthy mice that received nifedipine i.a. compared to the healthy control group where no treatment was administered, and the MMD group that received nifedipine i.a. compared to the untreated MMD model group (Figure 12a). The gene discussed is LEP; the disease is multiminicore myopathy.