IGHE and Increased total eosinophil count: The role played by IL-4 is also emphasized in the production of immunoglobulin E (IgE) antibodies, the target of which is the immune cells that they sensitize for a subsequent encounter with the pathogen, at which point degranulation and the release of inflammatory molecules occur with both direct involvement (amplification of hypersensitivity, glycoprotein production and eosinophilia, similar to leukotrienes) and indirect involvement by stimulating mast cell maturation and IgE secretion [19,20].