Meanwhile, it is known that the promoter activity of rs36084323 with the A-allele is lower than the G-allele, and it may cause various autoimmune thyroid diseases by affecting the expression of PD-1 on Treg cells, the expression of PD-1/PD-1 ligand (PD-L1) on thyroid, and the titers of thyroglobulin autoantibody [31]. Here, CD274 is linked to autoimmune thyroid disease.