No differences were observed in the levels of anti-S1 IgG antibodies when we looked at the different IMRD diseases, but when we compared the humoral response of each IMRD disease with HC, rheumatoid arthritis and ankylosing spondylitis had lower titer levels (p < 0.01 and p < 0.05, respectively) (Figure 1C). This evidence concerns the gene PSMD1 and rheumatoid arthritis.