However, significant differences were seen when we compared IFN-γ titers of each IMRD disease with HC; rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis had lower titer levels (p  < 0.0001, p < 0.01, and p < 0.05, respectively) (Figure 2C). This evidence concerns the gene IFNG and ankylosing spondylitis.