The intricate interplay involving lncRNAs such as LINC00657, NEAT1, H19, and SNHG7, as well as multiple miRNAs, has emphasized their pivotal roles in the modulation of the immune response, cellular pathways like Wnt, MAPK, and PI3K/Akt/mTOR, and the progression of CRC. The gene discussed is AKT1; the disease is colorectal carcinoma.