SMAD4 and neoplasm: Figure 3 shows the protein-protein interactions derived from the 15 hub nodes (SMAD4, PARP1, FOXO1, CCND1, CREB1, CDKN1A, SMAD2, PTEN, AR, SP1, ETS1, RHOA, IGF1R, FOXO3, and IL6) in differentially expressed miRNAs between TN/tumor and benign tissues. The network between target genes was constructed using Cytoscape [20].