Although the molecular mechanism that leads to WAT browning related to cellular components of the TME is incompletely disentangled in CRC patients, it is considered that TNF-α, IL-1, IL-6, IL-8, and C-X-C motif chemokine ligand 8 (CXCL8) are the most relevant procachectic molecules, which are partially produced by tumor cells, CAAs, and immune-associated tumor cells [37]. Here, CXCL8 is linked to neoplasm.