Hypoxia also promotes the acetate uptake and hypoxia-inducible factor 1 (HIF-1) activation in colorectal cancer cells, which induces the sterol regulatory-element binding protein-1 (SREBP-1) and fatty acid synthase (FASN) overexpression, enzymes involved in de novo lipid synthesis [100]. The gene discussed is SREBF1; the disease is colorectal cancer.