The CRC tumor microenvironment (TME) is a heterogeneous milieu, consisting of colorectal tumor cells, cancer stem cells, and extracellular matrix components (collagen, laminin, elastin, and fibronectin) associated with a spectrum of nontumor cells, which include cancer-associated fibroblast (CAFs), endothelial cells, cancer-associated adipocytes (CAAs), pericytes, mesenchymal stromal cells, and immune cells [6]. Here, FN1 is linked to cancer.