Of particular note, in a meta-analysis of 63 cohort studies and 20 randomized controlled trials (RCT), the risk of stroke increased by 7% for every 10 mL/min/1.73 m2 decline in eGFR and by 10% per 25 mg/mmol increase in the albumin–creatinine ratio independently of GFR [7]. This evidence concerns the gene ALB and Stroke.