In contrast, the remaining six (67%) pro-inflammatory/pro-injury chemokines exhibited statistical trend increases (IP-10 and TNF-α), reductions (IL12p70,), or detectable differences (eotaxin, MIP-1α, MIP-1β, IL-8, and RANTES) in the MCI/AD group relative to the controls. This evidence concerns the gene CCL5 and Alzheimer disease.