The observed MCI/early-AD-associated modulations of seven CSF cytokines and chemokines in favor of increased inflammation, injury, or neurodegeneration, including TNF-α, IFN-γ, IL-5, IL-9, and IL-13, or reduced neuroprotection (PDGF-bb and GM-CSF) correspond with previous reports on AD [146,147]. The gene discussed is TNF; the disease is Alzheimer disease.