In addition, endothelin-1 can upregulate lipid metabolism genes and promote atherosclerotic lesions characterized by overexpression of endothelial-targeted endothelin-1 in mice; the blockage of the endothelin-A receptor leads to the restoration of endothelial function and the inhibition of atherosclerosis development in ApoE knockout mice [37,38]. Here, EDN1 is linked to atherosclerosis.