Generally, CAD-associated genes can be classified into three groups: disease-causing genes (LDLR, APOB, PCSK9, CYP7A1, ARH and ABCA1); susceptibility genes (USF1 and LTA); and disease-linked genes (ICAM2, PIM2, ECGF1, CXCR4, BL34, GOS8, ARHGAP4, RARA, RARB and ARRB2) [1]. The gene discussed is PCSK9; the disease is coronary artery disorder.