RA-A patients showed a significant decrease in anti-VCA IgM and anti-EA(D) IgM (p = 0.026 and p = 0.006, respectively), while in RA-B patients, the titers for anti-VCA IgG and anti-EA(D) IgG decreased significantly during the 6-Month follow-up (p = 0.006 and p = 0.006, respectively). The gene discussed is CD40LG; the disease is rheumatoid arthritis.