CD44 is a multi-functional transmembrane glycoprotein that not only mediates cell adhesion and cell migration, but also transduces various signaling pathways of intra- and intercellular events [11,22], thus activating a variety of cellular processes, such as migration, invasion, proliferation, and metastasis in cancer cells, including in GBM [23]. The gene discussed is CD44; the disease is glioblastoma.