The activation of STAT3 would also lead to various STAT3-dependent pathways, such as the interleukin-8/STAT3 (IL-8/STAT3) and EGFR/STAT3/SRY-box transcription factor 2 (EGFR/STAT3/SOX2) pathways, which have been shown to play important roles in cancer stemness [71,72]. The gene discussed is CXCL8; the disease is cancer.