Preclinical studies in HNSCC with actein, xanthohumol, fucoidan, ilimaquinone, nimbolide, 4-O-methylhonokiol, cinnamaldehyde, kaempferol, and fisetin have indicated higher a Bax/Bcl-2 ratio (upregulating Bax and/or downregulating Bcl-2) on the mitochondrial membrane, supporting the induction of intrinsic apoptosis of HNSCC [41,44,46,47,48,49,91,92]. This evidence concerns the gene BAX and head and neck squamous cell carcinoma.