AKT1 and neoplasm: The activation of complex signaling pathways, such as phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) and mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK), is important for tumor development, cell survival, and angiogenesis, while epithelial to mesenchymal transition (EMT) signaling leads to tumor invasion and migration [26,27].