MAPT and Alzheimer disease: In close agreement, ROCK knockdown in SH-SY5Y cells or its pharmacological inhibition in primary culture neurons contributed to a significant reduction in both tau mRNA and protein levels and to the decreased activation of mTOR, leading to the regulation of autophagy [275], thus supporting the clinical use of ROCK inhibitors as rational therapeutic approaches for AD and other tauopathies (NCT04734379).