In detail, immunohistochemical experiments allowed the observation of a significant reduction in the colocalization staining of TOMM20 (OMM protein) and LAMP2 (lysosomal protein), whilst electron microscopy images showed fewer mitophagy-like events in the postmortem hippocampal regions of AD patients relative to age-matched healthy controls, indicating mitophagy failure and the accumulation of compromised mitochondria in the hippocampi of AD patients [134]. The gene discussed is LAMP2; the disease is Alzheimer disease.