In detail, immunohistochemical experiments allowed the observation of a significant reduction in the colocalization staining of TOMM20 (OMM protein) and LAMP2 (lysosomal protein), whilst electron microscopy images showed fewer mitophagy-like events in the postmortem hippocampal regions of AD patients relative to age-matched healthy controls, indicating mitophagy failure and the accumulation of compromised mitochondria in the hippocampi of AD patients [134]. This evidence concerns the gene TOMM20 and Alzheimer disease.