Although the authors did not provide direct evidence of a causal link between AMPK–SIRT1–PGC-1α inhibition and Aβ25–35-induced mitochondrial biogenesis in hippocampal neurons, their findings support previous evidence about the important role that this signaling pathway has in rescuing mitochondrial defects by activating mitochondrial biogenesis in AD [126,127]. The gene discussed is PPARGC1A; the disease is Alzheimer disease.