UCP2 and Alzheimer disease: In line with this, Thangavel et al. demonstrated that AD brains presented increased expression of the proinflammatory protein glia maturation factor, which seemed to be related to the downregulation of both UCP2 and UCP4 expression and an increased proinflammatory environment in the parahippocampal gyrus in AD brains as compared to non-AD brains [285].