To investigate the applicability of ROCK inhibitors in AD, Hamano and colleagues [274] treated M1C cells (a human neuroblastoma cell line) overexpressing wild-type tau protein (4R0N) and a mouse model of tauopathy with three different ROCK inhibitors, H1152, Y-27632, and fasudil (HA-1077). The gene discussed is MAPT; the disease is tauopathy.