Besides S14G-humanin, Colivelin has been identified as another potent humanin derivate able to improve the AD pathological damage and associated impairments in learning and memory that occurred in APP/PS1 mice [217] and to prevent Aβ25–35-induced deficits in spatial memory and synaptic plasticity in rats [218]. The gene discussed is MT-RNR2; the disease is Alzheimer disease.