Studies have shown multiple elevated immune markers in both acute Lyme disease (IL-6, IL-8, IL-12, IL-18, IFN-γ, CXCL12, CXCL13) and PTLDS (IL-6, IL-23, IFN-α, CCL19) [46,47,48,49]. The gene discussed is IL6; the disease is Lyme disease.