GRN and obesity due to melanocortin 4 receptor deficiency: It is also important to note that the novel EC proteins, APP, CAD, BRD2 (which is part of DKFZp313H139), CST3, GRN, PPM1G and ZC3H4 [94,95,96,97,98,99,100], have all been reported to be positively associated with obesity or adiposity [94,95,96,97,98,99,100], whilst the novel EC protein SLC25A24 may even prevent obesity and promote leanness [101].