By expansion of immunosuppressive cells such as regulatory T cells (Treg), myeloid-derived suppressor cells (MDSC) or tumor-associated macrophages (TAM) [10,11,12] and concomitant contraction of immunostimulatory cells, including dendritic cells (DC), CD4 positive T helper cells (Th1), CD8 positive T cells (CD8+ T), natural killer cells (NK) and pro-inflammatory M1 like macrophages (M1), tumors suppress innate and adaptive anti-cancer mechanisms and escape from immunosurveillance [13,14,15,16,17]. This evidence concerns the gene CD4 and neoplasm.