MBTPS1 and melanoma: For example, in cancerous tissue of human endometrial cells, the level of DhCer was increased 3- to 4.6-fold, and Cer and S1P were increased 1.6- to 1.9-fold [125]; whereas in melanoma cells, DhCers and Cers were significantly lowered compared with non-malignant melanocytes [33].